PPP2CA
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that (in humans) is encoded by the PPP2CA gene.[5]
External IDsOMIM: 176915; MGI: 1321159; HomoloGene: 37660; GeneCards: PPP2CA; OMA:PPP2CA - orthologs
Function
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.[6]
Interactions
PPP2CA has been shown to interact with:
- Bcl-2,[7]
- Bestrophin 1,[8]
- CCNG2,[9]
- CTTNBP2NL,[10]
- CTTNBP2,[10]
- Cyclin-dependent kinase 2,[11]
- Cyclin-dependent kinase 6,[11]
- FAM40A,[10]
- IGBP1,[10][12][13][14]
- MOBKL3,[10]
- PPP2R1A,[10][15]
- PPP2R1B,[10][15]
- PPP2R2A,[10][16]
- PPP2R3B,[10][17]
- PPP2R5A,[10][18]
- PPP2R5B,[10][18]
- PPP2R5C,[10][18][19]
- PPP2R5D,[10][18]
- PPP2R5E,[10][18]
- STRN3,[10]
- STRN,[10] and
- TLX1.[20]