PPP2CB

Enzyme found in humans From Wikipedia, the free encyclopedia

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.[5]

AliasesPPP2CB, PP2Abeta, PP2CB, protein phosphatase 2 catalytic subunit beta
End30,814,314 bp[1]
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PPP2CB
Identifiers
AliasesPPP2CB, PP2Abeta, PP2CB, protein phosphatase 2 catalytic subunit beta
External IDsOMIM: 176916; MGI: 1321161; HomoloGene: 37889; GeneCards: PPP2CB; OMA:PPP2CB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004156
NM_001009552

NM_017374

RefSeq (protein)

NP_001009552

NP_059070

Location (UCSC)Chr 8: 30.77 – 30.81 MbChr 8: 34.09 – 34.11 Mb
PubMed search[3][4]
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Function

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.[6]

Interactions

PPP2CB has been shown to interact with TLX1,[7] PPP2R1B[8] and PPP2R1A.[8][9]

See also

References

Further reading

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