PPP2R2B

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.^[5][6]

AliasesPPP2R2B, B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12, protein phosphatase 2 regulatory subunit Bbeta

External IDsOMIM: 604325; MGI: 1920180; HomoloGene: 55833; GeneCards: PPP2R2B; OMA:PPP2R2B - orthologs

Chr.Chromosome 5 (human)^[1]

End147,084,784 bp^[1]

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PPP2R2B
Identifiers
Aliases	PPP2R2B, B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12, protein phosphatase 2 regulatory subunit Bbeta
External IDs	OMIM: 604325; MGI: 1920180; HomoloGene: 55833; GeneCards: PPP2R2B; OMA:PPP2R2B - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 146,580,742 bp[1] End 147,084,784 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 42,770,497 bp[2] End 43,216,192 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm ganglionic eminence prefrontal cortex caudate nucleus nucleus accumbens Brodmann area 23 putamen endothelial cell primary visual cortex dorsolateral prefrontal cortex Top expressed in entorhinal cortex perirhinal cortex neural layer of retina CA3 field primary motor cortex anterior amygdaloid area visual cortex primary visual cortex central gray substance of midbrain subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein serine/threonine phosphatase activity protein phosphatase regulator activity Cellular component cytoplasm mitochondrial outer membrane cytoskeleton membrane mitochondrion protein phosphatase type 2A complex cytosol Biological process apoptotic process mitotic cell cycle peptidyl-serine dephosphorylation developmental process regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5521 72930 Ensembl ENSG00000156475 ENSMUSG00000024500 UniProt Q00005 Q6ZWR4 RefSeq (mRNA) NM_001271899 NM_001271900 NM_001271948 NM_181674 NM_181675 NM_181676 NM_181677 NM_181678 NM_027531 NM_028392 RefSeq (protein) NP_001258828 NP_001258829 NP_001258877 NP_858060 NP_858061 NP_858062 NP_858063 NP_858064 NP_082668 NP_081807 NP_001390894 Location (UCSC) Chr 5: 146.58 – 147.08 Mb Chr 18: 42.77 – 43.22 Mb PubMed search [3] [4]
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The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.^[7]