PPP2R2C

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.[5][6][7]

AliasesPPP2R2C, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma, B55gamma
End6,563,600 bp[1]
Quick facts Identifiers, Aliases ...
PPP2R2C
Identifiers
AliasesPPP2R2C, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma, B55gamma
External IDsOMIM: 605997; MGI: 2442660; HomoloGene: 36386; GeneCards: PPP2R2C; OMA:PPP2R2C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_172994
NM_001360003

RefSeq (protein)

NP_766582
NP_001346932

Location (UCSC)Chr 4: 6.32 – 6.56 MbChr 5: 37.03 – 37.11 Mb
PubMed search[3][4]
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Function

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

Further reading

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