PPP2R5B

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.[5][6]

AliasesPPP2R5B, B56B, PR61B, protein phosphatase 2 regulatory subunit B'beta, B56beta
End64,934,475 bp[1]
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PPP2R5B
Identifiers
AliasesPPP2R5B, B56B, PR61B, protein phosphatase 2 regulatory subunit B'beta, B56beta
External IDsOMIM: 601644; MGI: 2388480; HomoloGene: 38157; GeneCards: PPP2R5B; OMA:PPP2R5B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006244

NM_198168

RefSeq (protein)

NP_006235

NP_937811

Location (UCSC)Chr 11: 64.92 – 64.93 MbChr 19: 6.28 – 6.29 Mb
PubMed search[3][4]
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Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily.[6]

Interactions

PPP2R5B has been shown to interact with PPP2R1B[7] and PPP2CA.[7][8]

References

Further reading

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