PPP2R5C

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesPPP2R5C, B56G, PR61G, protein phosphatase 2 regulatory subunit B'gamma, B56gamma
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PPP2R5C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPP2R5C, B56G, PR61G, protein phosphatase 2 regulatory subunit B'gamma, B56gamma
External IDsOMIM: 601645; MGI: 1349475; HomoloGene: 135298; GeneCards: PPP2R5C; OMA:PPP2R5C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 14: 101.76 – 101.93 MbChr 12: 110.41 – 110.55 Mb
PubMed search[3][4]
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Function

The product of this gene belongs to the Protein phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

Interactions

PPP2R5C has been shown to interact with PPP2R1B,[7] PPP2CA[7][8][9] and PPP2R5A.[10]

References

Further reading

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