PPP2R5E

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.[5][6]

AliasesPPP2R5E, protein phosphatase 2 regulatory subunit B'epsilon, B56epsilon, B56E
End63,543,377 bp[1]
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PPP2R5E
Identifiers
AliasesPPP2R5E, protein phosphatase 2 regulatory subunit B'epsilon, B56epsilon, B56E
External IDsOMIM: 601647; MGI: 1349473; HomoloGene: 55962; GeneCards: PPP2R5E; OMA:PPP2R5E - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012024

RefSeq (protein)

NP_036154

Location (UCSC)Chr 14: 63.37 – 63.54 MbChr 12: 75.5 – 75.64 Mb
PubMed search[3][4]
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Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily.[6]

Interactions

PPP2R5E has been shown to interact with PPP2R1B[7] and PPP2CA.[7][8]

References

Further reading

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