PRDM2
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.[5][6]
Function
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[6]
Interactions
PRDM2 has been shown to interact with Estrogen receptor alpha[7] and Retinoblastoma protein.[5]
