Prolargin

Prolargin is a protein that in humans is encoded by the PRELP gene.^[5]

AliasesPRELP, MST161, MSTP161, SLRR2A, proline/arginine-rich end leucine-rich repeat protein, proline and arginine rich end leucine rich repeat protein

External IDsOMIM: 601914; MGI: 2151110; HomoloGene: 2041; GeneCards: PRELP; OMA:PRELP - orthologs

Chr.Chromosome 1 (human)^[1]

End203,491,352 bp^[1]

Quick facts PRELP, Identifiers ...

PRELP
Identifiers
Aliases	PRELP, MST161, MSTP161, SLRR2A, proline/arginine-rich end leucine-rich repeat protein, proline and arginine rich end leucine rich repeat protein
External IDs	OMIM: 601914; MGI: 2151110; HomoloGene: 2041; GeneCards: PRELP; OMA:PRELP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 203,475,806 bp[1] End 203,491,352 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 58.02 cM Start 133,838,042 bp[2] End 133,849,152 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein right coronary artery synovial joint popliteal artery ascending aorta tibial arteries pericardium Descending thoracic aorta left coronary artery tibia Top expressed in ankle aortic valve brown adipose tissue white adipose tissue right lung calvaria ascending aorta sciatic nerve right lung lobe Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding extracellular matrix structural constituent extracellular matrix structural constituent conferring compression resistance Cellular component extracellular matrix Golgi lumen extracellular vesicle lysosomal lumen extracellular exosome extracellular space extracellular region collagen-containing extracellular matrix Biological process skeletal system development keratan sulfate biosynthetic process keratan sulfate catabolic process axonogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5549 116847 Ensembl ENSG00000188783 ENSMUSG00000041577 UniProt P51888 Q9JK53 RefSeq (mRNA) NM_201348 NM_002725 NM_054077 RefSeq (protein) NP_002716 NP_958505 NP_473418 Location (UCSC) Chr 1: 203.48 – 203.49 Mb Chr 1: 133.84 – 133.85 Mb PubMed search [3] [4]
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The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson–Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.^[5]