PREX2

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene.^[5][6]

AliasesPREX2, 6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

External IDsOMIM: 612139; MGI: 1923385; HomoloGene: 23523; GeneCards: PREX2; OMA:PREX2 - orthologs

Chr.Chromosome 8 (human)^[1]

End68,237,032 bp^[1]

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PREX2
Identifiers
Aliases	PREX2, 6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
External IDs	OMIM: 612139; MGI: 1923385; HomoloGene: 23523; GeneCards: PREX2; OMA:PREX2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.2 Start 67,952,046 bp[1] End 68,237,032 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A2 Start 11,063,689 bp[2] End 11,373,905 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon endothelial cell visceral pleura corpus callosum ventricular zone parietal pleura epithelium of colon adipose tissue subcutaneous adipose tissue caudate nucleus Top expressed in left lung lobe lobe of cerebellum cerebellar vermis zygote sciatic nerve lateral septal nucleus tail of embryo otolith organ right lung utricle More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity guanyl-nucleotide exchange factor activity Cellular component cytoplasm plasma membrane cytosol Biological process adult locomotory behavior phosphatidylinositol 3-kinase signaling G protein-coupled receptor signaling pathway regulation of Rho protein signal transduction intracellular signal transduction dendrite morphogenesis positive regulation of GTPase activity negative regulation of protein kinase activity negative regulation of TOR signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80243 109294 Ensembl ENSG00000046889 ENSMUSG00000048960 UniProt Q70Z35 Q3LAC4 RefSeq (mRNA) NM_024870 NM_025170 NM_001033636 NM_029525 RefSeq (protein) NP_079146 NP_079446 NP_001028808 NP_083801 Location (UCSC) Chr 8: 67.95 – 68.24 Mb Chr 1: 11.06 – 11.37 Mb PubMed search [3] [4]
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