PRIM2

DNA primase large subunit in humans is encoded by the PRIM2 gene and is part of the enzyme DNA polymerase alpha.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesPRIM2, PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2

External IDsOMIM: 176636; MGI: 97758; HomoloGene: 731; GeneCards: PRIM2; OMA:PRIM2 - orthologs

Chr.Chromosome 6 (human)^[1]

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PRIM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L9Q, 3Q36, 4BPU, 4BPW, 4BPX, 4RR2, 5F0Q, 5EXR, 5F0S
Identifiers
Aliases	PRIM2, PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2
External IDs	OMIM: 176636; MGI: 97758; HomoloGene: 731; GeneCards: PRIM2; OMA:PRIM2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p11.2 Start 57,314,805 bp[1] End 57,646,850 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 12.7 cM|1 B Start 33,492,891 bp[2] End 33,708,876 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell gonad ganglionic eminence Achilles tendon ventricular zone testicle oocyte epithelium of colon stromal cell of endometrium rectum Top expressed in fetal liver hematopoietic progenitor cell secondary oocyte genital tubercle maxillary prominence primary oocyte mandibular prominence medial ganglionic eminence tail of embryo cumulus cell spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity transferase activity DNA binding 4 iron, 4 sulfur cluster binding iron-sulfur cluster binding nucleotidyltransferase activity metal ion binding single-stranded DNA binding DNA-directed DNA polymerase activity DNA primase activity protein binding Cellular component nucleoplasm alpha DNA polymerase:primase complex Biological process DNA replication DNA replication, synthesis of RNA primer DNA biosynthetic process telomere maintenance via semi-conservative replication G1/S transition of mitotic cell cycle DNA replication initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5558 19076 Ensembl ENSG00000146143 ENSMUSG00000026134 UniProt P49643 P33610 RefSeq (mRNA) NM_000947 NM_001282487 NM_001282488 NM_008922 RefSeq (protein) NP_000938 NP_001269416 NP_001269417 NP_032948 Location (UCSC) Chr 6: 57.31 – 57.65 Mb Chr 1: 33.49 – 33.71 Mb PubMed search [3] [4]
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The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.^[6]