PRiMA functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.[4] This is accomplished by the proline rich anchor domain (PRAD) of PRIMA1 which anchors the tetramer of AChE into the plasma membrane of neural cells and myocytes.[6] The PRAD interacts with the C-terminal T-peptide of AChE.[7]
PRiMA plays a role in targeting AChE to the cell surface and, in neuroblastoma cells, PRiMA the limiting factor of such targeting.[5] In both mice and humans, PRiMA exists as two alternative splice variants that differ in their cytoplasmic regions.
