PRPF4

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that is found in humans and encoded by the PRPF4 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesPRPF4, HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60, pre-mRNA processing factor 4

External IDsOMIM: 607795; MGI: 1917302; HomoloGene: 3446; GeneCards: PRPF4; OMA:PRPF4 - orthologs

Chr.Chromosome 9 (human)^[1]

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PRPF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MZW, 3JCR
Identifiers
Aliases	PRPF4, HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60, pre-mRNA processing factor 4
External IDs	OMIM: 607795; MGI: 1917302; HomoloGene: 3446; GeneCards: PRPF4; OMA:PRPF4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 113,275,642 bp[1] End 113,294,009 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B3 Start 62,327,034 bp[2] End 62,345,227 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte corpus epididymis cartilage tissue endothelial cell islet of Langerhans tail of epididymis caput epididymis embryo Skeletal muscle tissue of biceps brachii ventricular zone Top expressed in hand maxillary prominence epiblast mandibular prominence foot yolk sac interventricular septum primitive streak cumulus cell superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function U4 snRNA binding protein binding U6 snRNA binding Cellular component Cajal body nuclear speck spliceosomal complex spliceosomal snRNP complex U4/U6 snRNP nucleoplasm U4/U6 x U5 tri-snRNP complex nucleus U2-type precatalytic spliceosome Biological process RNA splicing, via transesterification reactions mRNA processing RNA processing RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9128 70052 Ensembl ENSG00000136875 ENSMUSG00000066148 UniProt O43172 Q9DAW6 RefSeq (mRNA) NM_001244926 NM_004697 NM_001322266 NM_001322267 NM_027297 RefSeq (protein) NP_001231855 NP_001309195 NP_001309196 NP_004688 NP_081573 Location (UCSC) Chr 9: 113.28 – 113.29 Mb Chr 4: 62.33 – 62.35 Mb PubMed search [3] [4]
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The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors.

PRPF4 is 1 of several proteins that associates with U4 and U6 snRNPs.[supplied by OMIM]^[7]