PRSS22

Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.^[5][6][7]

AliasesPRSS22, BSSP-4, hBSSP-4, SP001LA, protease, serine 22, serine protease 22

External IDsOMIM: 609343; MGI: 1918085; HomoloGene: 23344; GeneCards: PRSS22; OMA:PRSS22 - orthologs

Chr.Chromosome 16 (human)^[1]

End2,858,170 bp^[1]

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PRSS22
Identifiers
Aliases	PRSS22, BSSP-4, hBSSP-4, SP001LA, protease, serine 22, serine protease 22
External IDs	OMIM: 609343; MGI: 1918085; HomoloGene: 23344; GeneCards: PRSS22; OMA:PRSS22 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,852,730 bp[1] End 2,858,170 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.18 cM Start 24,212,508 bp[2] End 24,217,074 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa minor salivary glands gallbladder body of pancreas right uterine tube prostate tonsil vagina right lobe of thyroid gland left lobe of thyroid gland Top expressed in conjunctival fornix lip transitional epithelium of urinary bladder cornea superior cervical ganglion epithelium of lens external carotid artery esophagus internal carotid artery ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type endopeptidase activity hydrolase activity serine-type peptidase activity Cellular component extracellular region extrinsic component of plasma membrane anchored component of plasma membrane Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64063 70835 Ensembl ENSG00000005001 ENSG00000282937 ENSMUSG00000045027 UniProt Q9GZN4 Q9ER10 RefSeq (mRNA) NM_022119 NM_133731 RefSeq (protein) NP_071402 NP_598492 Location (UCSC) Chr 16: 2.85 – 2.86 Mb Chr 17: 24.21 – 24.22 Mb PubMed search [3] [4]
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This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.^[5]