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Trypsin-3

Enzyme found in humans From Wikipedia, the free encyclopedia

Trypsin-3 (also called Mesotrypsin or Serine protease 3) is an enzyme that in humans is encoded by the PRSS3 gene.[5] Like other trypsins, trypsin-3 is a digestive enzyme which is secreted in an inactive form as part of pancreatic juice.[6] Trypsin-3 is distinctive in its resistance to common trypsin inhibitors and expression in the brain in addition to the pancreas.[5]

AliasesPRSS3, MTG, PRSS4, T9, TRY3, TRY4, protease, serine 3, serine protease 3
External IDsOMIM: 613578; MGI: 102757; GeneCards: PRSS3
PDBOrtholog search: PDBe RCSB
Quick facts PRSS3, Identifiers ...
PRSS3
Identifiers
AliasesPRSS3, MTG, PRSS4, T9, TRY3, TRY4, protease, serine 3, serine protease 3
External IDsOMIM: 613578; MGI: 102757; GeneCards: PRSS3
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
3.4.21.4↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001197097
NM_001197098
NM_002771
NM_007343

NM_011646

RefSeq (protein)

NP_001184026
NP_001184027
NP_002762
NP_031369

NP_035776

Location (UCSC)Chr 9: 33.75 – 33.8 MbChr 6: 41.28 – 41.28 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and the acinar cells of the pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

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