PRX-14040

PRX-14040 is a selective dopamine reuptake inhibitor that was developed by Prexa Pharmaceuticals.^[1][2][3] It has 28-fold selectivity for the dopamine transporter over the norepinephrine transporter.^[2] Similarly to various other dopamine reuptake inhibitors, the drug has been found to reverse motivational deficits induced by the dopamine depleting agent tetrabenazine in animals.^[1][2]

Other namesPRX14040

Drug classDopamine reuptake inhibitor; Pro-motivational agent

CAS Number

• 1664382-90-4 ^Y

PubChem CID

• 117903522

Quick facts Clinical data, Other names ...

PRX-14040

Clinical data
Other names	PRX14040
Drug class	Dopamine reuptake inhibitor; Pro-motivational agent
Identifiers
IUPAC name 5-(2-(1-(3,4-dichlorophenyl)cyclobutyl)-2-hydroxyethyl)-2-oxa-5-azoniabicyclo[2.2.1]heptane chloride
CAS Number	1664382-90-4 Y
PubChem CID	117903522
Chemical and physical data
Formula	C17H22Cl3NO2
Molar mass	378.72 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CC(C1)(C2=CC(=C(C=C2)Cl)Cl)C(C[NH+]3CC4CC3CO4)O.[Cl-]
InChI InChI=1S/C17H21Cl2NO2.ClH/c18-14-3-2-11(6-15(14)19)17(4-1-5-17)16(21)9-20-8-13-7-12(20)10-22-13;/h2-3,6,12-13,16,21H,1,4-5,7-10H2;1H Key:QAHXUHUHCQYFHC-UHFFFAOYSA-N

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