PTK6
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[5][6][7]
External IDsOMIM: 602004; MGI: 99683; HomoloGene: 68494; GeneCards: PTK6; OMA:PTK6 - orthologs
Function
Tyrosine-protein kinase 6—also known as BRK[7] (breast tumor kinase)—is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[7]
Clinical significance
Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[7]
