PTPN14

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesPTPN14, PEZ, PTP36, protein tyrosine phosphatase, non-receptor type 14, CATLPH, protein tyrosine phosphatase non-receptor type 14, PTPD2
Quick facts Available structures, PDB ...
PTPN14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN14, PEZ, PTP36, protein tyrosine phosphatase, non-receptor type 14, CATLPH, protein tyrosine phosphatase non-receptor type 14, PTPD2
External IDsOMIM: 603155; MGI: 102467; HomoloGene: 3941; GeneCards: PTPN14; OMA:PTPN14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005401

NM_001033287
NM_008976

RefSeq (protein)

NP_005392

NP_033002

Location (UCSC)Chr 1: 214.35 – 214.55 MbChr 1: 189.46 – 189.61 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.[6]

Interactions

PTPN14 has been shown to interact with Beta-catenin.[7]

References

Further reading

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