PTPN4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesPTPN4, MEG, PTPMEG, PTPMEG1, protein tyrosine phosphatase, non-receptor type 4, protein tyrosine phosphatase non-receptor type 4
Quick facts Available structures, PDB ...
PTPN4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN4, MEG, PTPMEG, PTPMEG1, protein tyrosine phosphatase, non-receptor type 4, protein tyrosine phosphatase non-receptor type 4
External IDsOMIM: 176878; MGI: 1099792; HomoloGene: 2120; GeneCards: PTPN4; OMA:PTPN4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002830

NM_019933

RefSeq (protein)

NP_002821

NP_064317

Location (UCSC)Chr 2: 119.76 – 119.98 MbChr 1: 119.65 – 119.84 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.[6]

Interactions

PTPN4 has been shown to interact with GRID2.[7]

References

Further reading

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