PURB

PURB
Identifiers
Aliases	PURB, PURBETA, purine-rich element binding protein B, purine rich element binding protein B
External IDs	OMIM: 608887; MGI: 1338779; HomoloGene: 69087; GeneCards: PURB; OMA:PURB - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,885,530 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,425,917 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; cerebellar vermis; ; pancreatic epithelial cell; ; gingival epithelium; ; pancreatic ductal cell; ; visceral pleura; ; Brodmann area 23; ; tibialis anterior muscle; ; epithelium of nasopharynx; ; myocardium of left ventricle;
	Top expressed in
	lateral septal nucleus; ; anterior amygdaloid area; ; Region I of hippocampus proper; ; primary motor cortex; ; piriform cortex; ; olfactory tubercle; ; cingulate gyrus; ; superior colliculus; ; lateral geniculate nucleus; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA binding; double-stranded DNA binding; SMAD binding; single-stranded DNA binding; transcription factor binding; mRNA binding; RNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; purine-rich negative regulatory element binding; sequence-specific DNA binding;
Cellular component	DNA replication factor A complex; nucleus;
Biological process	regulation of myeloid cell differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; cell population proliferation; cell differentiation; transcription, DNA-templated; negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	5814
	19291
	ENSG00000146676
	ENSMUSG00000094483
	Q96QR8
	O35295
	NM_033224
	NM_011221
	NP_150093
	NP_035351
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.^[5]^[6]

AliasesPURB, PURBETA, purine-rich element binding protein B, purine rich element binding protein B

External IDsOMIM: 608887; MGI: 1338779; HomoloGene: 69087; GeneCards: PURB; OMA:PURB - orthologs

Chr.Chromosome 7 (human)^[1]

End44,885,530 bp^[1]

Quick facts Identifiers, Aliases ...

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This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.

Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.^[6]

[5]

[6]

[1]

[2]

[3]

[4]

PURB

References

Further reading

Related Articles

Related Articles

"Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"Human Chromosome 7: DNA Sequence and Biology"

"Large-scale characterization of HeLa cell nuclear phosphoproteins"

"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"