Pentedrone
Stimulant designer drug of the cathinone class
From Wikipedia, the free encyclopedia
Pentedrone (also known as α-methylaminovalerophenone) is a stimulant of the cathinone class that has been sold as a designer drug and has been found since 2010 as an ingredient in a number of "bath salt" mixes sold as legal highs.[3][4][5][6][7][8][9]
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- BR: Class F2 (Prohibited psychotropics)[1]
- DE: Anlage II (Authorized trade only, not prescriptible)
- UK: Class B
- US: Schedule I
- UN: Psychotropic Schedule II[2]
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| Other names | α-Methylaminovalerophenone; α-Propyl-β-keto-N-methylphenethylamine; α-Desmethyl-α-propyl-N-methylcathinone; α-Desmethyl-α-propylmethcathinone; α-Desmethyl-α-propyl-β-keto-N-methylamphetamine; α-Desmethyl-α-propyl-β-ketomethamphetamine |
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| ECHA InfoCard | 100.231.338 |
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| Formula | C12H17NO |
| Molar mass | 191.274 g·mol−1 |
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Pharmacology
Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor (NDRI) without inducing monoamine release, a similar mechanism of action to methylphenidate.[10][11] Its IC50 values for inhibition of monoamine reuptake have been reported to be 610 nM for norepinephrine, 2,500 μM for dopamine, and 135,000 μM for serotonin.[10] In rodents, pentedrone has been found to produce conditioned place preference (CPP), to be self-administered, and to dose-dependently stimulate locomotor activity.[11] Hence, pentedrone shows psychostimulant-like and reinforcing effects in animals.[11]
Side effects
Detection
A forensic standard of pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[13]
Legal status
On January 28, 2014, the DEA listed it, along with nine other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.[14]
Pentedrone is an Anlage II controlled drug in Germany.
As of October 2015 Pentedrone is a controlled substance in China.[15]
Pentedrone is banned in the Czech Republic.[16]
Pentedrone is banned in the Slovak Republic.[17]