Periciazine

Periciazine (INN), also known as pericyazine (BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics.^[3]

Pregnancy
category

AU: C

Routes of
administrationOral

Drug classTypical antipsychotic

ATC code

N05AC01 (WHO)

Quick facts Clinical data, Pregnancycategory ...

Periciazine
Clinical data

Pregnancy category	AU: C
Routes of administration	Oral
Drug class	Typical antipsychotic
ATC code	N05AC01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) BR: Class C1 (Other controlled substances)^[1] CA: ℞-only UK: POM (Prescription only) In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic (mostly via conjugation)^[2]
Elimination half-life	12 h^[2]
Excretion	Renal^[2]
Identifiers
IUPAC name 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
CAS Number	2622-26-6^Y
PubChem CID	4747
DrugBank	DB01608^N
ChemSpider	4585^N
UNII	3405M6FD73
KEGG	D01485^Y
ChEBI	CHEBI:31981^N
ChEMBL	ChEMBL251940^N
CompTox Dashboard (EPA)	DTXSID5045910
ECHA InfoCard	100.018.248
Chemical and physical data
Formula	C₂₁H₂₃N₃OS
Molar mass	365.50 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
InChI InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2^N Key:LUALIOATIOESLM-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Close

Periciazine is not approved for sale in the United States. It is commonly sold in Canada, Italy and Russia under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.^[4]

Medical uses

The primary uses of periciazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia. There is insufficient evidence to determine whether periciazine is more or less effective than other antipsychotics.^[2] Dopamine receptor subtype analysis has not been performed for pericyazine, but the drug appears to induce greater noradrenergic than dopaminergic blockade (Nishikawa 1989). Compared to chlorpromazine, pericyazine reportedly has more potent antiemetic, antiserotonin, and anticholinergic activity.^[5] A 2014 systematic review compared periciazine with typical antipsychotics for schizophrenia:

More information Summary, Outcome ...

Periciazine versus typical antipsychotic for schizophrenia^[5]

Summary

On the basis of very low quality evidence it is not possible to determine the effects of periciazine in comparison with antipsychotics such as chlorpromazine or trifluoperazine for the treatment of schizophrenia. There is some evidence, however, that periciazine may be associated with a higher incidence of extrapyramidal side effects than other antipsychotics.^[5]

Outcome	Findings in words	Findings in numbers	Quality of evidence
Global state
Not improved Follow-up: 6-12 weeks	Periciazine may increase the risk of being 'not improved', but, at present it is not possible to be confident about the difference between people receiving periciazine and those given chlorpromazine or trifluoperazine. Data supporting this finding are very limited.	RR 1.24 (0.93 to 1.66)	Very low
Adverse events
Extrapyramidal side effect Follow-up: 6-12 weeks	Periciazine may reduce the chance of experiencing the movement disorder, compared with chlorpromazine or trifluoperazine, but, at present there is only very limited data supporting this finding.	RR 0.59 (0.38 to 0.89)	Very low
Leaving the study early
For any reasons Follow-up: 9-12 weeks	Periciazine may reduce the chance of leaving the study early, but, at present it is not possible to be confident about the difference between the two treatments and data supporting this finding are very limited.	RR 0.46 (0.11 to 1.9)	Very low
Missing outcomes
	No study reported any data on outcomes such as relapse, mental state, cost-effectiveness, and information relating to behavior

Close

Periciazine has also been studied in the treatment of opioid dependence.^[6]

Adverse effects

Periciazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low.^[7] It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.^[7]

Medical uses

Adverse effects

References

External links

Related Articles