Pholedrine
Chemical compound
From Wikipedia, the free encyclopedia
Pholedrine, also known as 4-hydroxy-N-methylamphetamine and sold under the brand names Paredrinol, Pulsotyl, and Veritol among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil.[1][2][3] It can be used to diagnose Horner's syndrome.[3]
administrationTopical (ocular)
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| Trade names | Paredrinol, Presoitan, Pulsotyl, Veritain, Veritol |
| Other names | 4-Hydroxy-N-methylamphetamine; 4-HMA; 4-Hydroxymethamphetamine; para-Hydroxymethamphetamine; PHMA; Hydroxymethamphetamine |
| Routes of administration | Topical (ocular) |
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| ECHA InfoCard | 100.006.114 |
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| Formula | C10H15NO |
| Molar mass | 165.236 g·mol−1 |
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In 2004, it remained marketed only in Germany.[1][needs update]
Pharmacology
Pharmacodynamics
Pholedrine is described as a sympathomimetic, antihypotensive, and ephedrine-like agent.[4][1][5]
Chemistry
Pholedrine, also known as 4-hydroxy-N-methylamphetamine, is a substituted phenethylamine and amphetamine derivative.[4][1] It is structurally related to methamphetamine (N-methylamphetamine), norpholedrine (4-hydroxyamphetamine), oxilofrine (4,β-dihydroxy-N-methylamphetamine), and tyramine (4-hydroxyphenethylamine).
It is used pharmaceutically as the sulfate salt.[1][4]
The predicted log P of pholedrine ranges from 1.12 to 1.7.[2][6][7]
History
Pholedrine was synthesized by 1951.[4]
Society and culture
Other drugs
Pholedrine (4-hydroxymethamphetamine) is also a major metabolite of methamphetamine.