PreQ1 synthase
From Wikipedia, the free encyclopedia
PreQ1 synthase (EC 1.7.1.13) is an enzyme that catalyzes the chemical reaction
| PreQ1 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.7.1.13 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The substrates of this enzyme are 7-cyano-7-deazaguanine, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and two protons. Its products are 7-aminomethyl-7-deazaguanine and oxidised NADP+.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase. Other names in common use include YkvM, QueF, preQ0 reductase, preQ0 oxidoreductase, 7-cyano-7-deazaguanine reductase, 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase, queuine synthase and queuine:NADP+ oxidoreductase: (the last two are misleading as queuine is not the product). The enzyme is part of the biosynthetic pathway to modified nucleoside, queuosine.[4][5][6][7] As of 2012[update], this was the only enzyme known to directly catalyze the reduction of a nitrile group to a primary amine.[8]
