Estradiol benzoate/hydroxyprogesterone caproate
Combination drug
From Wikipedia, the free encyclopedia
Estradiol benzoate/hydroxyprogesterone caproate (EB/OHPC), sold under the brand name Primosiston among others, is a combined estrogen and progestogen medication which is used to treat gynecological disorders and habitual abortion.[1][2][3][4][5] It contains estradiol benzoate (EB), an estrogen, and hydroxyprogesterone caproate (OHPC), a progestin.[1][2][3][4][5] The medication is given by injection into muscle.[1][2][3][4][5]
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 | |
| Combination of | |
|---|---|
| Estradiol benzoate | Estrogen |
| Hydroxyprogesterone caproate | Progestogen |
| Clinical data | |
| Trade names | Primosiston, others |
| Other names | EB/OHPC |
| Routes of administration | Intramuscular injection |
| ATC code | |
| Identifiers | |
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Medical uses
EB/OHPC is used in the treatment of gynecological disorders such as menstrual disorders (e.g., amenorrhea, dysfunctional uterine bleeding) and premenstrual syndrome, habitual abortion (threatened miscarriage), and for other indications.[1][2][3][4]
Available forms
EB/OHPC is available in the form of ampoules of oil solutions containing 10 mg estradiol benzoate (EB) and 125 to 250 mg hydroxyprogesterone caproate (OHPC).[1][2][3][4][5]
History
EB/OHPC was first introduced for medical use in 1955.[6]
Society and culture
Brand names
EB/OHPC has been marketed under brand names including Dos Dias N, Lutes, Ostrolut, Primosiston (or Primosiston Inj. / Injection), Primosiston Fuerte, and Syngynon.[7][8][9]
Availability
EB/OHPC has been mostly discontinued and hence is mostly no longer available.[7][8][9] It remains marketed under the brand names Primosiston in Ecuador and Peru, Dos Dias N in Argentina, and Lutes in Japan.[7][8][9] It was previously marketed under the brand names Ostrolut in Austria; Primosiston (or Primosiston Inj. / Injection) (Schering)[1][2][4] in Argentina, Germany, Mexico, Switzerland, and Venezuela; Primosiston Fuerte in Spain; and Syngynon in Germany, but these formulations have all been discontinued and hence are no longer available in these countries.[7][8][9]
