Proheptazine

Proheptazine is an opioid analgesic related to pethidine. It was invented in the 1960s.^[2]

ATC code

• none

Legal status

• AU: S9 (Prohibited substance)
• BR: Class A1 (Narcotic drugs)^[1]
• CA: Schedule I
• DE: Anlage I (Authorized scientific use only)
• US: Schedule I

CAS Number

• 77-14-5

PubChem CID

• 60969

Quick facts Clinical data, ATC code ...

Proheptazine

Clinical data
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited substance) BR: Class A1 (Narcotic drugs)[1] CA: Schedule I DE: Anlage I (Authorized scientific use only) US: Schedule I
Identifiers
IUPAC name 1,3-Dimethyl-4-phenylazepan-4-yl propionate
CAS Number	77-14-5
PubChem CID	60969
ChemSpider	54931 Y
UNII	S23189WW7E
KEGG	D12677 Y
CompTox Dashboard (EPA)	DTXSID50861628
ECHA InfoCard	100.000.916
Chemical and physical data
Formula	C17H25NO2
Molar mass	275.392 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(OC2(c1ccccc1)CCCN(C)CC2C)CC
InChI InChI=1S/C17H25NO2/c1-4-16(19)20-17(15-9-6-5-7-10-15)11-8-12-18(3)13-14(17)2/h5-7,9-10,14H,4,8,11-13H2,1-3H3 Y Key:ZXWAUWBYASJEOE-UHFFFAOYSA-N Y
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Proheptazine produces similar effects to other opioids,^[3] including analgesia, sedation, euphoria, dizziness and nausea.

In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9643 and a 2013 annual aggregate manufacturing quota of zero. The salts in use are the citrate (free base conversion ratio 0.589), hydrobromide (0.773), and hydrochloride (0.883).^[4][5]