QKI

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesQKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding

External IDsOMIM: 609590; MGI: 97837; HomoloGene: 11059; GeneCards: QKI; OMA:QKI - orthologs

Chr.Chromosome 6 (human)^[1]

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QKI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JVH
Identifiers
Aliases	QKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding
External IDs	OMIM: 609590; MGI: 97837; HomoloGene: 11059; GeneCards: QKI; OMA:QKI - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q26 Start 163,414,000 bp[1] End 163,578,592 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 7.75 cM Start 10,421,530 bp[2] End 10,538,783 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell dorsal motor nucleus of vagus nerve corpus callosum inferior olivary nucleus inferior ganglion of vagus nerve external globus pallidus pars reticulata subthalamic nucleus superior vestibular nucleus internal globus pallidus Top expressed in Gonadal ridge otic placode saccule sciatic nerve left lung lobe deep cerebellar nuclei substantia nigra cumulus cell lateral geniculate nucleus tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein binding nucleic acid binding mRNA binding RNA binding Cellular component cytoplasm nucleus synapse Biological process cell differentiation mRNA transport mRNA processing vasculogenesis multicellular organism development axon ensheathment muscle cell differentiation positive regulation of gene expression long-chain fatty acid biosynthetic process RNA splicing spermatid development myelination 3'-UTR-mediated mRNA destabilization regulation of translation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9444 19317 Ensembl ENSG00000112531 ENSMUSG00000062078 UniProt Q96PU8 Q9QYS9 RefSeq (mRNA) NM_001301085 NM_006775 NM_206853 NM_206854 NM_206855 NM_001159516 NM_001159517 NM_021881 RefSeq (protein) NP_001288014 NP_006766 NP_996735 NP_996736 NP_996737 NP_001152988 NP_001152989 NP_068681 Location (UCSC) Chr 6: 163.41 – 163.58 Mb Chr 17: 10.42 – 10.54 Mb PubMed search [3] [4]
Wikidata
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QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.^[7] They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1.^[8] Two more new members are KHDRBS3^[9] and KHDRBS2.^[10]

The QKI gene is implicated as being important in schizophrenia,^[11][12] and QKI controls translation of many oligodendrocyte-related genes.