RAB3A

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene.^[5][6][7] It is involved in calcium-triggered exocytosis in neurons.

AliasesRAB3A, member RAS oncogene family

External IDsOMIM: 179490; MGI: 97843; HomoloGene: 20629; GeneCards: RAB3A; OMA:RAB3A - orthologs

Chr.Chromosome 19 (human)^[1]

End18,204,042 bp^[1]

Quick facts Identifiers, Aliases ...

RAB3A
Identifiers
Aliases	RAB3A, member RAS oncogene family
External IDs	OMIM: 179490; MGI: 97843; HomoloGene: 20629; GeneCards: RAB3A; OMA:RAB3A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,196,784 bp[1] End 18,204,042 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.15 cM Start 71,207,328 bp[2] End 71,211,323 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum Brodmann area 9 prefrontal cortex nucleus accumbens amygdala putamen hypothalamus cingulate gyrus spinal ganglia Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell cerebellar cortex central gray substance of midbrain subiculum dorsomedial hypothalamic nucleus prefrontal cortex habenula primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase binding GTP binding myosin V binding protein C-terminus binding protein binding ATPase activator activity GTP-dependent protein binding GTPase activity GDP-dissociation inhibitor binding Cellular component extracellular vesicle endosome clathrin-sculpted monoamine transport vesicle membrane membrane synaptic vesicle plasma membrane clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane clathrin-sculpted acetylcholine transport vesicle membrane axon terminal bouton acrosomal vesicle intracellular organelle clathrin-sculpted glutamate transport vesicle membrane cytosol secretory granule membrane anchored component of synaptic vesicle membrane vesicle protein-containing complex presynaptic active zone secretory granule perinuclear region of cytoplasm Biological process respiratory system process positive regulation of ATP-dependent activity axonogenesis lung development synaptic vesicle exocytosis regulation of short-term neuronal synaptic plasticity evoked neurotransmitter secretion mitochondrion organization response to electrical stimulus post-embryonic development constitutive secretory pathway maintenance of presynaptic active zone structure glutamate secretion regulation of exocytosis regulation of synaptic vesicle fusion to presynaptic active zone membrane neuromuscular synaptic transmission synaptic vesicle recycling sensory perception of touch protein transport positive regulation of exocytosis synaptic vesicle maturation neurotransmitter secretion positive regulation of regulated secretory pathway exocytosis neutrophil degranulation post-translational protein modification transport intracellular protein transport vesicle docking involved in exocytosis protein secretion Rab protein signal transduction protein localization to plasma membrane plasma membrane repair regulation of synaptic vesicle priming synaptic vesicle transport acrosomal vesicle exocytosis regulation of synaptic vesicle exocytosis calcium-ion regulated exocytosis synaptic vesicle clustering Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5864 19339 Ensembl ENSG00000105649 ENSMUSG00000031840 UniProt P20336 P63011 RefSeq (mRNA) NM_002866 NM_001166399 NM_009001 NM_001328047 NM_001378892 NM_001378893 RefSeq (protein) NP_002857 NP_002857.1 NP_001159871 NP_001314976 NP_033027 NP_001365821 NP_001365822 Location (UCSC) Chr 19: 18.2 – 18.2 Mb Chr 8: 71.21 – 71.21 Mb PubMed search [3] [4]
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