RAB7B

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.[5]

AliasesRAB7B, RAB7, member RAS oncogene family
End206,003,461 bp[1]
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RAB7B
Identifiers
AliasesRAB7B, RAB7, member RAS oncogene family
External IDsMGI: 2442295; HomoloGene: 64833; GeneCards: RAB7B; OMA:RAB7B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164522
NM_001304839
NM_177403

NM_145509
NM_001311096

RefSeq (protein)

NP_001157994
NP_001291768
NP_796377

NP_001298025
NP_663484

Location (UCSC)Chr 1: 205.98 – 206 MbChr 1: 131.62 – 131.64 Mb
PubMed search[3][4]
Wikidata
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Function

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.[6] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.[6]

References

Further reading

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