RAB7B
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.[5]
External IDsMGI: 2442295; HomoloGene: 64833; GeneCards: RAB7B; OMA:RAB7B - orthologs
Function
Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.[6] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.[6]