RAB8A
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.[5][6][7]
Function
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no link between MEL and melanoma has been demonstrated. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.[7]
Interactions
RAB8A has been shown to interact with Optineurin[8] and MAP4K2.[9]
