RAP2B

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene.^[5][6] RAP2B belongs to the Ras-related protein family.

PDBOrtholog search: PDBe RCSB

AliasesRAP2B, member of RAS oncogene family

External IDsOMIM: 179541; MGI: 1921262; HomoloGene: 55701; GeneCards: RAP2B; OMA:RAP2B - orthologs

Chr.Chromosome 3 (human)^[1]

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RAP2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N4P, 1N4Q, 1N4R, 1N4S
Identifiers
Aliases	RAP2B, member of RAS oncogene family
External IDs	OMIM: 179541; MGI: 1921262; HomoloGene: 55701; GeneCards: RAP2B; OMA:RAP2B - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.2 Start 153,162,226 bp[1] End 153,170,627 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E1 Start 61,269,059 bp[2] End 61,275,851 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium germinal epithelium buccal mucosa cell amniotic fluid tendon of biceps brachii mucosa of pharynx hair follicle human penis palpebral conjunctiva secondary oocyte Top expressed in aortic valve cumulus cell ascending aorta epithelium of lens lumbar subsegment of spinal cord Rostral migratory stream tibiofemoral joint calvaria external carotid artery dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein domain specific binding GDP binding GTP binding protein binding GTPase activity Cellular component recycling endosome cytosol endosome membrane cell-cell contact zone bicellular tight junction recycling endosome membrane membrane raft extracellular exosome plasma membrane specific granule membrane tertiary granule membrane Biological process regulation of protein tyrosine kinase activity microvillus assembly establishment of endothelial intestinal barrier Rap protein signal transduction platelet activation negative regulation of cell migration positive regulation of protein autophosphorylation platelet aggregation signal transduction neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5912 74012 Ensembl ENSG00000181467 ENSMUSG00000036894 UniProt P61225 P61226 RefSeq (mRNA) NM_002886 NM_028712 RefSeq (protein) NP_002877 NP_082988 Location (UCSC) Chr 3: 153.16 – 153.17 Mb Chr 3: 61.27 – 61.28 Mb PubMed search [3] [4]
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This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.^[6]