RAPGEF5

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesRAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF

External IDsOMIM: 609527; MGI: 2444365; HomoloGene: 56563; GeneCards: RAPGEF5; OMA:RAPGEF5 - orthologs

Chr.Chromosome 7 (human)^[1]

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RAPGEF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGY
Identifiers
Aliases	RAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF
External IDs	OMIM: 609527; MGI: 2444365; HomoloGene: 56563; GeneCards: RAPGEF5; OMA:RAPGEF5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.3 Start 22,118,236 bp[1] End 22,357,154 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F2 Start 117,480,099 bp[2] End 117,723,472 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve pons inferior olivary nucleus corpus callosum superior vestibular nucleus pars reticulata subthalamic nucleus postcentral gyrus external globus pallidus dorsal motor nucleus of vagus nerve Top expressed in superior cervical ganglion otolith organ utricle anterior amygdaloid area right lung lateral septal nucleus zygote left lung lobe oocyte secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP-dependent protein binding guanyl-nucleotide exchange factor activity Cellular component nucleus nucleoplasm nuclear body Biological process small GTPase mediated signal transduction nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9771 217944 Ensembl ENSG00000136237 ENSMUSG00000041992 UniProt Q92565 Q8C0Q9 RefSeq (mRNA) NM_012294 NM_001367600 NM_001367601 NM_001367602 NM_001367603 NM_175930 NM_001373989 RefSeq (protein) NP_036426 NP_001354529 NP_001354530 NP_001354531 NP_001354532 NP_787126 NP_001360918 Location (UCSC) Chr 7: 22.12 – 22.36 Mb Chr 12: 117.48 – 117.72 Mb PubMed search [3] [4]
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Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]^[7]