RARRES1

Retinoic acid receptor responder protein 1 is a protein that in humans is encoded by the RARRES1 gene.^[5][6][7]

AliasesRARRES1, LXNL, TIG1, PERG-1, retinoic acid receptor responder 1

External IDsOMIM: 605090; MGI: 1924461; HomoloGene: 2166; GeneCards: RARRES1; OMA:RARRES1 - orthologs

Chr.Chromosome 3 (human)^[1]

End158,732,489 bp^[1]

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RARRES1
Identifiers
Aliases	RARRES1, LXNL, TIG1, PERG-1, retinoic acid receptor responder 1
External IDs	OMIM: 605090; MGI: 1924461; HomoloGene: 2166; GeneCards: RARRES1; OMA:RARRES1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.32 Start 158,696,892 bp[1] End 158,732,489 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E1 Start 67,386,305 bp[2] End 67,422,856 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium palpebral conjunctiva olfactory zone of nasal mucosa left uterine tube germinal epithelium nasal epithelium gastric mucosa urethra parietal pleura tail of epididymis Top expressed in lip skin of external ear skin of abdomen lumbar spinal ganglion left lobe of liver skin of back seminal vesicula embryo spermatocyte esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metalloendopeptidase inhibitor activity Cellular component integral component of membrane membrane extracellular exosome extracellular space Biological process negative regulation of cell population proliferation negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5918 109222 Ensembl ENSG00000118849 ENSMUSG00000049404 UniProt P49788 n/a RefSeq (mRNA) NM_002888 NM_206963 NM_001164763 RefSeq (protein) NP_002879 NP_996846 n/a Location (UCSC) Chr 3: 158.7 – 158.73 Mb Chr 3: 67.39 – 67.42 Mb PubMed search [3] [4]
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This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.^[7]