RASA4

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.^[5][6]

AliasesRASA4, CAPRI, GAPL, RAS p21 protein activator 4

External IDsOMIM: 607943; MGI: 1858600; HomoloGene: 5080; GeneCards: RASA4; OMA:RASA4 - orthologs

Chr.Chromosome 7 (human)^[1]

End102,616,756 bp^[1]

Quick facts Identifiers, Aliases ...

RASA4
Identifiers
Aliases	RASA4, CAPRI, GAPL, RAS p21 protein activator 4
External IDs	OMIM: 607943; MGI: 1858600; HomoloGene: 5080; GeneCards: RASA4; OMA:RASA4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 102,579,646 bp[1] End 102,616,756 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 136,083,916 bp[2] End 136,111,860 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle skeletal muscle tissue sural nerve right coronary artery granulocyte myometrium body of uterus subcutaneous adipose tissue canal of the cervix Top expressed in primary oocyte Ileal epithelium zygote muscle of thigh secondary oocyte plantaris muscle neural layer of retina extensor digitorum longus muscle stroma of bone marrow ankle joint More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity metal ion binding phospholipid binding Cellular component cytoplasm cytosol membrane intrinsic component of the cytoplasmic side of the plasma membrane plasma membrane Biological process intracellular signal transduction regulation of GTPase activity MAPK cascade negative regulation of GTPase activity signal transduction positive regulation of GTPase activity negative regulation of Ras protein signal transduction cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10156 54153 Ensembl ENSG00000105808 ENSMUSG00000004952 UniProt O43374 Q6PFQ7 RefSeq (mRNA) NM_001079877 NM_006989 NM_001039103 NM_133914 RefSeq (protein) NP_001073346 NP_008920 NP_001034192 NP_598675 Location (UCSC) Chr 7: 102.58 – 102.62 Mb Chr 5: 136.08 – 136.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]