RASGRP3
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.[5][6][7]
External IDsOMIM: 609531; MGI: 3028579; HomoloGene: 15019; GeneCards: RASGRP3; OMA:RASGRP3 - orthologs
| RASGRP3 | |||||||||||||||||||||||||||||||
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| Aliases | RASGRP3, GRP3, RAS guanyl releasing protein 3 | ||||||||||||||||||||||||||||||
| External IDs | OMIM: 609531; MGI: 3028579; HomoloGene: 15019; GeneCards: RASGRP3; OMA:RASGRP3 - orthologs | ||||||||||||||||||||||||||||||
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Function
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[7]
