RASSF5

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesRASSF5, Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3, Ras association domain family member 5
Quick facts Available structures, PDB ...
RASSF5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRASSF5, Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3, Ras association domain family member 5
External IDsOMIM: 607020; MGI: 1926375; HomoloGene: 10296; GeneCards: RASSF5; OMA:RASSF5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182665
NM_031437
NM_182663
NM_182664

NM_018750
NM_001311094
NM_001313731

RefSeq (protein)

NP_872604
NP_872605
NP_872606

NP_001298023
NP_001300660
NP_061220

Location (UCSC)Chr 1: 206.51 – 206.59 MbChr 1: 131.1 – 131.17 Mb
PubMed search[3][4]
Wikidata
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Function

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

RASSF5 has been shown to interact with RRAS,[8] RAP2A,[8] MRAS[8] and RASSF1.[8]

References

Further reading

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