RBBP6

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Retinoblastoma-binding protein 6 is a protein that in humans is encoded by the RBBP6 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesRBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA, retinoblastoma binding protein 6, RB binding protein 6, ubiquitin ligase
Quick facts Available structures, PDB ...
RBBP6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA, retinoblastoma binding protein 6, RB binding protein 6, ubiquitin ligase
External IDsOMIM: 600938; MGI: 894835; HomoloGene: 136812; GeneCards: RBBP6; OMA:RBBP6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006910
NM_018703
NM_032626

NM_011247
NM_175023

RefSeq (protein)

NP_008841
NP_061173
NP_116015

NP_035377
NP_778188
NP_001390011
NP_001390012

Location (UCSC)Chr 16: 24.54 – 24.57 MbChr 7: 122.56 – 122.6 Mb
PubMed search[3][4]
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Function

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.[7]

Interactions

RBBP6 has been shown to interact with Y box binding protein 1.[8]

References

Further reading

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