RBBP7
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.[5]
AliasesRBBP7, RbAp46, retinoblastoma binding protein 7, RB binding protein 7, chromatin remodeling factor
External IDsOMIM: 300825; MGI: 1194910; HomoloGene: 55702; GeneCards: RBBP7; OMA:RBBP7 - orthologs
Function
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.[6]