RBBP8
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.[5][6][7]
Function
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.[7]
DNA repair
RBBP8 is involved in the DNA repair process of homologous recombination.[8] It was proposed that, in gastric cancer cells, inhibition of RBBP8 expression could cause a synthetic lethal effect along with PARP inhibitor treatment.[8]