RBM15

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene.^[5][6][7] It is an RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m⁶A) methylation of RNAs^[8]

AliasesRBM15, OTT, OTT1, SPEN, RNA binding motif protein 15, Putative RNA-binding protein 15

External IDsOMIM: 606077; MGI: 2443205; HomoloGene: 23383; GeneCards: RBM15; OMA:RBM15 - orthologs

Chr.Chromosome 1 (human)^[1]

End110,346,681 bp^[1]

Quick facts Identifiers, Aliases ...

RBM15
Identifiers
Aliases	RBM15, OTT, OTT1, SPEN, RNA binding motif protein 15, Putative RNA-binding protein 15
External IDs	OMIM: 606077; MGI: 2443205; HomoloGene: 23383; GeneCards: RBM15; OMA:RBM15 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 110,338,506 bp[1] End 110,346,681 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.3 Start 107,232,737 bp[2] End 107,240,989 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm endothelial cell Brodmann area 23 gingival epithelium Epithelium of choroid plexus middle temporal gyrus parietal pleura visceral pleura epithelium of nasopharynx Top expressed in ciliary body gastrula lacrimal gland submandibular gland abdominal wall primitive streak retinal pigment epithelium fossa endothelial cell of lymphatic vessel condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding mRNA binding Cellular component nuclear speck nuclear membrane membrane nucleus nucleoplasm nuclear envelope RNA N6-methyladenosine methyltransferase complex Biological process branching involved in blood vessel morphogenesis ventricular septum morphogenesis mRNA splicing, via spliceosome placenta blood vessel development viral process negative regulation of myeloid cell differentiation spleen development negative regulation of transcription, DNA-templated positive regulation of transcription of Notch receptor target regulation of alternative mRNA splicing, via spliceosome RNA methylation dosage compensation by inactivation of X chromosome thrombopoietin-mediated signaling pathway regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64783 229700 Ensembl ENSG00000162775 ENSMUSG00000048109 UniProt Q96T37 Q0VBL3 RefSeq (mRNA) NM_001201545 NM_022768 NM_014092 NM_001045807 RefSeq (protein) NP_001188474 NP_073605 NP_001039272 Location (UCSC) Chr 1: 110.34 – 110.35 Mb Chr 3: 107.23 – 107.24 Mb PubMed search [3] [4]
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