This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5] RBM3 contains a poison exon whose inclusion is lowered during hypothermia.[6]
RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects.[7] According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues[8] and based on confocal microscopy mainly localised to the nucleoplasm.[9]
