RCBTB2

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.^[5][6]

AliasesRCBTB2, CHC1L, RLG, RCC1 and BTB domain containing protein 2

External IDsOMIM: 603524; MGI: 1917200; HomoloGene: 970; GeneCards: RCBTB2; OMA:RCBTB2 - orthologs

Chr.Chromosome 13 (human)^[1]

End48,533,256 bp^[1]

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RCBTB2
Identifiers
Aliases	RCBTB2, CHC1L, RLG, RCC1 and BTB domain containing protein 2
External IDs	OMIM: 603524; MGI: 1917200; HomoloGene: 970; GeneCards: RCBTB2; OMA:RCBTB2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.2 Start 48,488,963 bp[1] End 48,533,256 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 73,360,477 bp[2] End 73,445,283 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte optic nerve parietal pleura visceral pleura Epithelium of choroid plexus retinal pigment epithelium seminal vesicula ganglionic eminence ventricular zone Top expressed in otic vesicle saccule otic placode mandibular prominence thymus maxillary prominence somite ventricular zone brown adipose tissue genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component acrosomal vesicle cytoplasmic vesicle Biological process regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1102 105670 Ensembl ENSG00000136161 ENSMUSG00000022106 UniProt O95199 Q99LJ7 RefSeq (mRNA) NM_001268 NM_001286830 NM_001286831 NM_001286832 NM_001352424 NM_001352425 NM_001352426 NM_001352427 NM_001352428 NM_001352429 NM_001352430 NM_001352431 NM_001170694 NM_134083 RefSeq (protein) NP_001259 NP_001273759 NP_001273760 NP_001273761 NP_001339353 NP_001339354 NP_001339355 NP_001339356 NP_001339357 NP_001339358 NP_001339359 NP_001339360 NP_001164165 NP_598844 Location (UCSC) Chr 13: 48.49 – 48.53 Mb Chr 14: 73.36 – 73.45 Mb PubMed search [3] [4]
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This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.^[6]