Reticulocalbin 2

Reticulocalbin-2 is a protein that in humans is encoded by the RCN2 gene.^[5][6][7]

AliasesRCN2, E6BP, ERC-55, ERC55, TCBP49, reticulocalbin 2

External IDsOMIM: 602584; MGI: 1349765; HomoloGene: 2176; GeneCards: RCN2; OMA:RCN2 - orthologs

Chr.Chromosome 15 (human)^[1]

End76,954,393 bp^[1]

Quick facts RCN2, Identifiers ...

RCN2
Identifiers
Aliases	RCN2, E6BP, ERC-55, ERC55, TCBP49, reticulocalbin 2
External IDs	OMIM: 602584; MGI: 1349765; HomoloGene: 2176; GeneCards: RCN2; OMA:RCN2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.3 Start 76,931,738 bp[1] End 76,954,393 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 55,949,129 bp[2] End 55,969,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis tibia caput epididymis embryo ventricular zone ganglionic eminence cartilage tissue retinal pigment epithelium endometrium tail of epididymis Top expressed in saccule otic placode dorsomedial hypothalamic nucleus spermatocyte paraventricular nucleus of hypothalamus mammillary body arcuate nucleus lateral hypothalamus median eminence otic vesicle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 5955 26611 Ensembl ENSG00000117906 ENSMUSG00000032320 UniProt Q14257 Q8BP92 RefSeq (mRNA) NM_002902 NM_001271837 NM_001278274 NM_011992 RefSeq (protein) NP_001258766 NP_002893 NP_001265203 NP_036122 Location (UCSC) Chr 15: 76.93 – 76.95 Mb Chr 9: 55.95 – 55.97 Mb PubMed search [3] [4]
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Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder.^[7]