RCP9

DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene.^[5][6][7][8]

AliasesCRCP, CGRP-RCP, CGRPRCP, RCP, RCP9, CGRP receptor component, RPC9, POLR3I, POLR3J, C17

External IDsOMIM: 606121; MGI: 1100818; HomoloGene: 40587; GeneCards: CRCP; OMA:CRCP - orthologs

Chr.Chromosome 7 (human)^[1]

End66,154,568 bp^[1]

Quick facts CRCP, Identifiers ...

CRCP
Identifiers
Aliases	CRCP, CGRP-RCP, CGRPRCP, RCP, RCP9, CGRP receptor component, RPC9, POLR3I, POLR3J, C17
External IDs	OMIM: 606121; MGI: 1100818; HomoloGene: 40587; GeneCards: CRCP; OMA:CRCP - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.21 Start 66,114,604 bp[1] End 66,154,568 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 130,058,131 bp[2] End 130,089,630 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence islet of Langerhans right lobe of liver monocyte oocyte rectum amniotic fluid stromal cell of endometrium prefrontal cortex Top expressed in dentate gyrus of hippocampal formation granule cell spermatocyte barrel cortex motor neuron Paneth cell endothelial cell of lymphatic vessel lens trigeminal ganglion seminiferous tubule morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding RNA polymerase III activity DNA-directed 5'-3' RNA polymerase activity protein binding catalytic activity calcitonin gene-related peptide receptor activity Cellular component cytosol membrane plasma membrane nucleoplasm acrosomal vesicle DNA polymerase III complex nucleus RNA polymerase III complex nuclear DNA-directed RNA polymerase complex RNA polymerase complex Biological process immune system process cell metabolism defense response to virus neuropeptide signaling pathway transcription by RNA polymerase III innate immune response DNA-templated transcription, initiation transcription initiation from RNA polymerase III promoter positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27297 12909 Ensembl ENSG00000241258 ENSMUSG00000025532 UniProt O75575 O35427 RefSeq (mRNA) NM_001040647 NM_001040648 NM_001142414 NM_014478 NM_007761 RefSeq (protein) NP_001035737 NP_001035738 NP_001135886 NP_055293 NP_031787 Location (UCSC) Chr 7: 66.11 – 66.15 Mb Chr 5: 130.06 – 130.09 Mb PubMed search [3] [4]
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This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[8]