RECK

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene,^[5] thought to be a metastasis suppressor.

AliasesRECK, ST15, reversion inducing cysteine rich protein with kazal motifs

External IDsOMIM: 605227; MGI: 1855698; HomoloGene: 9622; GeneCards: RECK; OMA:RECK - orthologs

Chr.Chromosome 9 (human)^[1]

End36,124,455 bp^[1]

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RECK
Identifiers
Aliases	RECK, ST15, reversion inducing cysteine rich protein with kazal motifs
External IDs	OMIM: 605227; MGI: 1855698; HomoloGene: 9622; GeneCards: RECK; OMA:RECK - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 36,036,913 bp[1] End 36,124,455 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 43,875,530 bp[2] End 43,944,806 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of hip parietal pleura skin of thigh germinal epithelium tibia stromal cell of endometrium visceral pleura lactiferous duct synovial joint Achilles tendon Top expressed in iris dermis calvaria left lung lobe vas deferens efferent ductule sciatic nerve skin of external ear ciliary body umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metalloendopeptidase inhibitor activity peptidase inhibitor activity endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity Wnt-protein binding coreceptor activity involved in canonical Wnt signaling pathway Cellular component anchored component of membrane membrane extracellular region plasma membrane Wnt signalosome Biological process vasculature development regulation of canonical Wnt signaling pathway negative regulation of metalloendopeptidase activity negative regulation of peptidase activity negative regulation of cell migration embryonic forelimb morphogenesis embryo implantation blood vessel maturation extracellular matrix organization sprouting angiogenesis Wnt signaling pathway regulation of angiogenesis canonical Wnt signaling pathway regulation of establishment of blood-brain barrier positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8434 53614 Ensembl ENSG00000122707 ENSMUSG00000028476 UniProt O95980 Q9Z0J1 RefSeq (mRNA) NM_001316345 NM_001316346 NM_001316347 NM_001316348 NM_021111 NM_016678 RefSeq (protein) NP_001303275.1 NP_001303276.1 NP_001303277.1 NP_001303274 NP_001303275 NP_001303276 NP_001303277 NP_066934 NP_057887 Location (UCSC) Chr 9: 36.04 – 36.12 Mb Chr 4: 43.88 – 43.94 Mb PubMed search [3] [4]
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The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.^[5] It is one of the targets of an oncomiR, MIRN21.