RELT

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Tumor necrosis factor receptor superfamily member 19L is a protein that in humans is encoded by the RELT gene.[5][6][7][8][9]

AliasesRELT, TNFRSF19L, TRLT, RELT tumor necrosis factor receptor, TNF receptor, RELT TNF receptor, AI3C
End73,397,474 bp[1]
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RELT
Identifiers
AliasesRELT, TNFRSF19L, TRLT, RELT tumor necrosis factor receptor, TNF receptor, RELT TNF receptor, AI3C
External IDsOMIM: 611211; MGI: 2443373; HomoloGene: 13151; GeneCards: RELT; OMA:RELT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032871
NM_152222

NM_177073
NM_001358914

RefSeq (protein)

NP_116260
NP_689408

NP_796047
NP_001345843

Location (UCSC)Chr 11: 73.38 – 73.4 MbChr 7: 100.5 – 100.51 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.[9]

References

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