RENBP

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.^[5][6]

AliasesRENBP, RBP, RNBP, renin binding protein

External IDsOMIM: 312420; MGI: 105940; HomoloGene: 2184; GeneCards: RENBP; OMA:RENBP - orthologs

Chr.X chromosome (human)^[1]

End153,944,687 bp^[1]

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RENBP
Identifiers
Aliases	RENBP, RBP, RNBP, renin binding protein
External IDs	OMIM: 312420; MGI: 105940; HomoloGene: 2184; GeneCards: RENBP; OMA:RENBP - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,935,269 bp[1] End 153,944,687 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.49 cM Start 72,965,727 bp[2] End 72,974,456 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spleen granulocyte right adrenal cortex upper lobe of left lung right lung C1 segment tibial nerve left adrenal cortex right coronary artery Top expressed in morula yolk sac right kidney blastocyst gastrula human kidney stroma of bone marrow calvaria proximal tubule iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme inhibitor activity endopeptidase inhibitor activity catalytic activity isomerase activity ATP binding protein homodimerization activity purine nucleotide binding N-acylglucosamine 2-epimerase activity peptidase inhibitor activity Cellular component extracellular exosome cytosol Biological process N-acetylmannosamine metabolic process regulation of blood pressure N-acetylneuraminate catabolic process negative regulation of catalytic activity negative regulation of endopeptidase activity N-acetylglucosamine metabolic process UDP-N-acetylglucosamine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5973 19703 Ensembl ENSG00000102032 ENSMUSG00000031387 UniProt P51606 P82343 RefSeq (mRNA) NM_002910 NM_001164704 NM_023132 RefSeq (protein) NP_002901 NP_001158176 NP_075621 Location (UCSC) Chr X: 153.94 – 153.94 Mb Chr X: 72.97 – 72.97 Mb PubMed search [3] [4]
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The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.^[6]