GUCY2F

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Retinal guanylyl cyclase 2 also known as guanylate cyclase F (GUCY2F) is a protein that in humans is encoded by the GUCY2F gene.[5]

AliasesGUCY2F, CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2, guanylate cyclase 2F, retinal
End109,482,086 bp[1]
Quick facts Identifiers, Aliases ...
GUCY2F
Identifiers
AliasesGUCY2F, CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2, guanylate cyclase 2F, retinal
External IDsOMIM: 300041; MGI: 105119; HomoloGene: 37491; GeneCards: GUCY2F; OMA:GUCY2F - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001522

NM_001007576

RefSeq (protein)

NP_001513

NP_001007577

Location (UCSC)Chr X: 109.37 – 109.48 MbChr X: 140.86 – 140.98 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein.[5]

Clinical significance

Defects in this gene may be a cause of X-linked retinitis pigmentosa.[5]

References

Further reading

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