RGPD5

RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5 gene.^[5][6][7]

AliasesRGPD5, BS-63, BS63, HEL161, RGP5, RANBP2-like and GRIP domain containing 5, RANBP2 like and GRIP domain containing 5

External IDsOMIM: 612708; MGI: 894323; HomoloGene: 87808; GeneCards: RGPD5; OMA:RGPD5 - orthologs

Chr.Chromosome 2 (human)^[1]

End109,857,705 bp^[1]

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RGPD5
Identifiers
Aliases	RGPD5, BS-63, BS63, HEL161, RGP5, RANBP2-like and GRIP domain containing 5, RANBP2 like and GRIP domain containing 5
External IDs	OMIM: 612708; MGI: 894323; HomoloGene: 87808; GeneCards: RGPD5; OMA:RGPD5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q13 Start 109,792,758 bp[1] End 109,857,705 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B4|10 29.34 cM Start 58,282,742 bp[2] End 58,330,178 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon buccal mucosa cell sural nerve trachea testicle nipple pylorus muscle of thigh bone marrow cell superior surface of tongue Top expressed in human fetus Gonadal ridge lobe of cerebellum lacrimal gland cerebellar vermis spermatocyte spermatid left lung lobe primitive streak pineal gland More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity Cellular component cytoplasm nucleus nuclear pore centrosome Biological process intracellular transport NLS-bearing protein import into nucleus positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84220 19386 Ensembl ENSG00000015568 ENSMUSG00000003226 UniProt Q99666 Q9ERU9 RefSeq (mRNA) NM_005054 NM_032260 NM_011240 RefSeq (protein) NP_005045 NP_115636 NP_035370 Location (UCSC) Chr 2: 109.79 – 109.86 Mb Chr 10: 58.28 – 58.33 Mb PubMed search [3] [4]
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RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.^[7]