RGS11

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.^[5][6]

AliasesRGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11

External IDsOMIM: 603895; MGI: 1354739; HomoloGene: 77719; GeneCards: RGS11; OMA:RGS11 - orthologs

Chr.Chromosome 16 (human)^[1]

End275,980 bp^[1]

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RGS11
Identifiers
Aliases	RGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11
External IDs	OMIM: 603895; MGI: 1354739; HomoloGene: 77719; GeneCards: RGS11; OMA:RGS11 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 268,301 bp[1] End 275,980 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 26,421,925 bp[2] End 26,430,298 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe anterior pituitary C1 segment cingulate gyrus anterior cingulate cortex tibial nerve amygdala Brodmann area 9 apex of heart Top expressed in neural layer of retina superior frontal gyrus morula primary visual cortex islet of Langerhans adrenal gland ganglion of vagus nerve autonomic nerve plexus CA3 field stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein beta-subunit binding GTPase activator activity GTPase activity Cellular component cytoplasm plasma membrane protein-containing complex intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway negative regulation of signal transduction intracellular signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8786 50782 Ensembl ENSG00000076344 ENSMUSG00000024186 UniProt O94810 Q9Z2H1 RefSeq (mRNA) NM_001286485 NM_001286486 NM_003834 NM_183337 NM_001081069 RefSeq (protein) NP_001273414 NP_001273415 NP_003825 NP_899180 NP_001074538 Location (UCSC) Chr 16: 0.27 – 0.28 Mb Chr 17: 26.42 – 26.43 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.^[6]